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Definitions by TheWitnessofDerfamine

derfamine 

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Hitting a corner three in the final seconds of a basketball game. Ultimately improving your social life and everything about you really. Or just being awesome as balls.
Dawsyn DeMott: Man Derf that three was wet!

Derf: It's derfamine..
Dawsyn DeMott: Man I want some derfamine!
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