derfamine 

Hitting a corner three in the final seconds of a basketball game. Ultimately improving your social life and everything about you really. Or just being awesome as balls.

Dawsyn DeMott: Man Derf that three was wet!

Derf: It's derfamine..
Dawsyn DeMott: Man I want some derfamine!

derfamine by TheWitnessofDerfamine June 21, 2016

Derpamine 

The drug emitted from the brain when one is derping on addictive social media sites. The more you derp, the more derpamine is emitted to keep you derping.

While I'm trying to have a conversation with him, Jeremy keeps checking his @'s for another hit of derpamine. What a cunt.

Derpamine by Jason_Chatfield August 28, 2013

defamination 

Removing hunger from people

I defaminated ethiopia

defamination by Justin September 11, 2003

Defamination 

/,defə' ən'meɪʃn/

noun-
hurting someone's feelings to a point that they use the word defamation incorrectly, going as far to spell it incorrectly.

witness: Do u want to take this to dms man?

defendant: So why in the fuck did you give them my face and do that art work, thats defamination : (

prosecutor: Didn't you say the n-word?

Defamination by CurseOfcrits March 26, 2023

dermaine 

The shit period

Dermaine is the shit fam

dermaine by Big Maine December 21, 2016

derminer 

Word used to temporary end a arguement.
Used at random to confuse opponent.

"well your mom is a hoe"
"well..well..DERMINER"

derminer by Ian Kellogg January 8, 2005

defamination 

the attempt to fire employees because they are small and Syrian

Steve is getting sued and shit for defamination

defamination by jpic May 3, 2007