1 definition by TheWitnessofDerfamine

Hitting a corner three in the final seconds of a basketball game. Ultimately improving your social life and everything about you really. Or just being awesome as balls.
Dawsyn DeMott: Man Derf that three was wet!

Derf: It's derfamine..
Dawsyn DeMott: Man I want some derfamine!
by TheWitnessofDerfamine April 6, 2016
Get the derfamine mug.