1 definition by Jeanniebean137
Similar to IBS,Irritable Friend Syndrome can occur when a friend unexpectantly morphs into an obnoxious bitch, but you have known them too long to severe the relationship.
Help me! I have serious IFS with my best friend since 7th grade and I don't know how to tell her to shut the hell up without hurting her feelings.
by Jeanniebean137 October 25, 2007