Quite simply a reference to being absolutely famished. In other words, if there’s something in the fridge that’s yours, or you’re trying to save, you better get that shit now. Every damn thing in there is about to be microwaved and devoured.
3am...wasted...: “Yo, I’m about to nuke the fridge, girl.”
homeowner: “Shit, girl, let me get that leftover Zaxby’s out of the way first.”