2 definitions by Cool_Hand_Luke

Taking a handful of Tylenol PM and then trying to have an orgasm before you fall asleep. Something that has been rumored as impossible by old people everywhere.
Hayden- "I just did 50 pull ups!"

Luke- "Please, I have completed the Tylenol PM challenge the past three nights in a row."

Hayden- "Nigger please, your shitting me"
by Cool_Hand_Luke December 1, 2013
Get the tylenol pm challenge mug.