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1.
The classiest way to respond to anyone you disagree with.
Obama: There are also those who claim that our reform efforts would insure illegal immigrants. This too is false - the reforms I'm proposing would not apply to those who are here illegally.

Joe Wilson: You lie!
by illicit_fun_owns September 09, 2009
12695 1979
 
2.
The (obviously) most classy way of politely telling someone that they are wrong. Take it from Joe.
Obama: I like pie.

Joe: YOU LIE!
by jazjaz130 September 11, 2009
462 199
 
3.
What Michelangelo shouted at Shredder when Shredder claims that Splinter is dead.
"You lie!"

"Do I?"
by jorgorthebarbarian September 10, 2009
295 111
 
4.
The easiest way to object to a statement for which you have no legitimate argument.
Obama: There are also those who claim that our reform efforts would insure illegal immigrants. This too is false - the reforms I'm proposing would not apply to those who are here illegally.

Joe Wilson: You lie!
by stating the obvious September 13, 2009
306 158
 
5.
What Leonardo shouted at Shredder when Shredder claimed that Splinter was dead.
Raphael: Where's Splinter?

Shredder: Ah, the rat. So it has a name. It had a name.

Leonardo: You lie!

Example 2:

jorgorthebarbarian: "You lie!" is what Michaelangelo shouted at Shredder when he claimed that Splinter was dead.

Me: You lie!
by shouldn't have apologized wuss September 27, 2009
69 33
 
6.
The douchiest way to respond to anyone you disagree with.
Obama: There are also those who claim that our reform efforts would insure illegal immigrants. This too is false - the reforms I'm proposing would not apply to those who are here illegally.

Joe Wilson: You lie!
by NightRaven September 12, 2009
206 173
 
7.
You lie? Is a short way to say "Are you lying?" or "Are you serious" Basically those. It is used when someone says something absolutely ridiculous and you think they are lying like the example below.
Bre--I'm related to Beyonce!
Jess--NO way!!
Bre--Yup! She's my half aunt!
Jess--You Lie?
Bre--Nope! It's the truth!
by Miss Crayzee May 22, 2009
9 29