Anything that can be acted on with confident success.
I'm guessing it originates from the fact that a wheelhouse is the room on the bridge of a ship where you steer from, providing you with clear view & control to steer the situation.
Have the handsome guy address that roomful of female sales potentials; it's right in his wheelhouse.

Singing this song in that key is right in your wheelhouse.

That pitch was thrown down & out, right in the batter's wheelhouse.

by ScottySlave October 29, 2007
Comedy Motor Home Option
"Get out of my wheelhouse!" ~ SSM
by KKM September 09, 2004
Location or area on the front of the human body between the neck and the abdomen.
The quarterback passed the ball to the receiver right in his wheelhouse.
by B Stanton September 19, 2005
someone's personal space. can be used when someone is in your face, or in your business.
dude, get back, your all up in my wheelhouse.
by fenderbender298 July 10, 2008
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