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1.
n. anus

"up the wazoo" - literal meaning, up one's trapdoor. can also mean an excess, or plentiful supply of
"That guy can't be our store's Santa! He's got child molestation convictions up the wazoo!"
by AJ Barrow June 25, 2005
 
2.
One's anal orifice.
Up your wazoo, asshat!
by eayte February 11, 2003
 
3.
your ass
havent you seen over the hedge
look at that girl's wazoo. OR
shit came out of my wazoo.
by JennyJacksoff November 26, 2007
 
4.
There is a respectable split among vernacularists whether "wazoo" applies to one's rump or one's porker. Ample weight for both definitions. See the delightful example below for both possible interpretations -- tuchus and ding-dong.

"How's your Father?
How's your Mother?
How's your charming sister Sue?
And, speaking of your family, how's your old Wazoo?"
by Madriaga October 09, 2003
 
5.
A self-important person of very little consequence: see esp. the Frank Zappa album "The Grand Wazoo" and the song titled "Cosmik Debris" (I think that spelling is correct).
"... with the oil of Aphrodite
and the dust of the Grand Wazoo
he said,
"you may not believe this, little fella,
but it'll cure your asthma, too!"
-Frank Zappa, from "Cosmik Debris"
by Peter GB September 25, 2007
 
6.
Pacific Northwest slang for Washington State University. Origin can be linked to the school's reputation of being a party college.
I unfortunately attended Wazoo for my undergrad.
by Sloppy Peas May 01, 2005
 
7.
the "fourth" hole
Yeah I want to shove a stick up his wazoo!
by anon987987654123 June 21, 2011