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A Canadian term for a 26-ounce bottle of alcohol. The modern bottle is actually 750 mL (25.36 oz), but it is still commonly called a two-six nonetheless. (See also: two-four.)
I finished off a two-six of rum in one evening, and did not feel good the next morning.
To crap. Also, a Deuce. Number Two.
The Todd: "I've got a Doozie of a Twosie!" - Scrubs
Twosie by D-Biz October 14, 2006
The word used to replace 'share' in a request to do so with someone.
Sam: ' I just brought a pack of gum'
Matt: ' Nice, wanna go twosies on it yeah? cool.'
Twosies by MDWatson June 29, 2008

twosie in the bank 

v. to need to poop, usually soon.
"Geez Hilty I got a twosie in the bank!"
twosie in the bank by Delta Sig January 3, 2008
N. defecation. Derived from the term number two. Originally used in the sitcom Scrubs.
"I gotta go making twosies."
twosies by Scrubby May 6, 2008
A latino street gang named after 26th ST in Chicago's Little Village community. The gang was originally a neighboorhood baseball team called the Two Sixers but formed as a street gang in the 1960's. One of Two six's biggest rivals is the Latin Kings.
Hey ese, look at that vato walkin down 26th, he wearin' black & tan, he must be a Two Six.