Top Definition
A non fatal illness that manifest itself in the chronic urge to twerk in inappropriate places.
After the episode in Wal-mart we thought meemaw had Parkinson's, but the Doctor said it was just an advanced case of twerkitis.
by ballz itchy July 11, 2014
1 more definition
The act of having the need to twerk every 10 sec.
"Damn nicole has Twerkitis, she be twerking more than Miley Cyrus!."
by TheDoctorXx September 11, 2013

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