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1.
A non fatal illness that manifest itself in the chronic urge to twerk in inappropriate places.
After the episode in Wal-mart we thought meemaw had Parkinson's, but the Doctor said it was just an advanced case of twerkitis.
by ballz itchy July 11, 2014
 
2.
The act of having the need to twerk every 10 sec.
"Damn nicole has Twerkitis, she be twerking more than Miley Cyrus!."
by TheDoctorXx September 11, 2013