to send a tweet in Greek
Hey did you see Matt's tweek? What did it mean?

Yeah, he told Amy how awesome the flaming cheese was in Greek... I google translated it.
by greektweeker February 1, 2011
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When you can't twerk, so you have to push your buttcheeks up and down to make them look like they are bouncing.
Guy1: Is that girl twerking or what?
Guy2: Naw man she's tweeking...
by Uhhhhhh123 February 4, 2014
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Also known as a foursome or orgy; Tweeking is when four participants of either the male, female or unspecified genders participate in fornicating with one another at the same time.
Ryan: Hey, you wanna' go tweeking?
Tweek: I'm in.
Chez Mix: Oh wait, Batman's not here. We need another person.
Tweek: God dammit.
by Batman>:( November 14, 2011
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When a girl plays with her Vag for pleasure or to tease men
My hoe girl friend was caught tweekin off at a party, all the guy seen her cookie
by Savoyo August 3, 2008
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Can be a state of paranoia, Have to urge to hurt or kill somebody, Be Extremely mad (sometimes because of drugs or mental ilnesses)
Im going to Tweek on someone very shortly!

by Mike AKA TweeK February 7, 2007
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Generally used as a verb to refer to what a DJ does to the knobs on the mixer.
Did you see that DJ tweek the knobs?
Tweekin' the knobs!
by katze April 19, 2005
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