Tweeking: A combination of two words, two and week. When you have been on meth (cranking in the old days) and up for two weeks you have a tendency to talk funny and slur your words. After two weeks when you try to tell someone what your problem is all you can say is "I tweek..." After coming down for a day before your next trip you realize that you said tweek and also realize that it is not only a homonym with tweak, which means to bend or force out of shape, but it can also be synonymous. And since you were very bent you think it is funny and go get an eightball, and your again tweeking in no time at all. This is the origin of the word, believe me I was there.

Moral of the Story: Don't do drugs
Pleeezzzze hlp ma, I tweeeeeeek blaaargghhh *thump*
In the next day or two after your regain consciousness you say; "Man I was tweeking."
by cawper January 9, 2008
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Tweeking is any change to a product or document that you think will take two hours but ends up taking two weeks. Tw(o)-(w)eeks.
The new website is ready to go, it just needs a little tweeking.
by BigMickSydney April 26, 2009
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To pinch or flick...

"I tweeked her nipple and she tweeked my clit with her tongue."
by Junebug December 14, 2005
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A smol chubby talented gay babey.
Appears on southpark. He's addicted to coffee and meth, and loves to play the piano. He's a good singer.
He and Craig Tucker are a couple. Like I said earlier, he gae.
TweekXCraig is my favorite episode!they were so gay in it! Especially Tweek!
by The_emo_bunny_ August 9, 2019
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An act of picking on someone caused by anxiousness for another high.
If you catch anyone tweeking, they're drug of choice is controlling 'em.
by Mr. Terrence L. Trezvant June 4, 2007
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Someone who Twitters obsessively on the social networking site "Twitter." Twitter + Geek = Tweek. Often appearing to be normal people on the surface, they will quickly reveal their inner geek whenever anyone mentions Twitter in a conversation, at which point they will tell everyone within earshot about all the hilarious and uninteresting things their friends and acquaintances have recently tweeted about.

See also "Twatter", someone who tries to accumulate a large following on Twitter in order to hide the fact that they are actually a giant twat.
Rational human: "I can't believe CNN is reporting on what politicians are tweeting from the halls of the Senate...or that politicians are tweeting in the halls of the senate, for that matter."

Tweek: "OMG I LOOOOOVE TWITTER!!! My friend Jessica just tweeted about how the guy next to her in line at the DMV just farted and she said it smells like a mix of hot garbage and a yeast infection!!! How funny is that?!"

Rational Human: "I hate your face."
by thepoolboy October 6, 2009
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Similar to a Gleek, the Tweek is the Twilight version. Geek + Twilight = Tweek
OMG I am sooo excited to go and see the new Twilight movie, I'm such a Tweek!!
by Sazilicious July 2, 2010
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