1) to be stimulated by consuming high amounts of caffeine or sugar.
2) to use amphetamine or methamphetamine.
i drank 3 monster drinks and ate a few candy bars at the skatepark and i was seriously tweakin'

a grip of anphetamine pills or a couple of lines of meth can cause you to tweaki all night.
by skaterjack October 05, 2006
To injure slightly, to sustain a slight injury to (some part of the body), usually while playing a sport.
"The pitcher tweaked his groin on a grounder back to the mound."
by RB Jr. July 18, 2006
To flip out
Dude, all I said was "hi" and he started tweakin'! What's his deal?
by Anonymous April 19, 2003
1. to go beyond extension, or stretching. as in the truth, a snowboard grab, or a body part.

2. to freak out while you're on drugs. (Usually used in correlation with meth users).
Hey, so you kind of tweaked the story a bit, I don't appreciate that.

Did you see him tweak that sick-ass stale fish?

Dude, I can't skate today-- I tweaked my ankle yesterday falling down 3 flights of stairs.

That Guy is fucking tweaking out. Someone shoot him with a super soaker!
by rustyn! September 26, 2008
To be paranoid/twitchy
To be High
Man, you gotta stop being so tweaky.
Man I was tweaking last night.
by Stewie April 08, 2003
To give a girl's clit a real workout, I mean, like when you give it the rub-a-dub taking it between your thumb and index. Not to be confused with mere twiddle.
I was giving her a real tweaking when her mother walked in on us.
by Hugh G Rection October 07, 2003
It's YOUR brand, do what ya' gotta do!
Dude, I helped TWEAK design a shoe!

The TWEAK Rhett & Link Mythical Shoes are the coolest shoes ever check them out!
by TWEAKfootwear April 04, 2011

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