8
1) to be stimulated by consuming high amounts of caffeine or sugar.
2) to use amphetamine or methamphetamine.
i drank 3 monster drinks and ate a few candy bars at the skatepark and i was seriously tweakin'

a grip of anphetamine pills or a couple of lines of meth can cause you to tweaki all night.
by skaterjack October 05, 2006
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9
To injure slightly, to sustain a slight injury to (some part of the body), usually while playing a sport.
"The pitcher tweaked his groin on a grounder back to the mound."
by RB Jr. July 18, 2006
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10
Dude, all I said was "hi" and he started tweakin'! What's his deal?
by Anonymous April 19, 2003
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11
1. to go beyond extension, or stretching. as in the truth, a snowboard grab, or a body part.

2. to freak out while you're on drugs. (Usually used in correlation with meth users).
Hey, so you kind of tweaked the story a bit, I don't appreciate that.

Did you see him tweak that sick-ass stale fish?

Dude, I can't skate today-- I tweaked my ankle yesterday falling down 3 flights of stairs.

That Guy is fucking tweaking out. Someone shoot him with a super soaker!
by rustyn! September 26, 2008
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12
To give a girl's clit a real workout, I mean, like when you give it the rub-a-dub taking it between your thumb and index. Not to be confused with mere twiddle.
I was giving her a real tweaking when her mother walked in on us.
by Hugh G Rection October 07, 2003
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13
To be paranoid/twitchy
To be High
Man, you gotta stop being so tweaky.
Man I was tweaking last night.
by Stewie April 08, 2003
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14
a legitmate word meaning to pluck, or pull, and other non slang variations, but the slang variant was originally used to indicate the stage of a drug induced high, usually immediately following dosing, that indicates the climax of the high and the shift from sobriety into being extreme intoxication. Users were left alone when they "tweak," or are "tweaking out" until the initial strong effects of the drug wore off a little and they were more coherent.

The term has come to loosely refer to being high on speed, as well as unfortunately children who have been exposed to meth amphetamines in utero, parodied on shows including South Park.
You might act a little crazy when you tweak, but you'll come down in a minute or two.
by Lady Artemis April 02, 2010
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