Tylenol 

A drug that cures your headache.

Son: “Mom I have a really bad headache.”

Mom “Okay I’ll get the Tylenol.”

Tylenol by HawaiianHotShot September 3, 2019

Tylenol 2

A combination of 300 mg acetaminophen, 15 mg caffeine, and 15 mg codeine.

CWE Tylenol 2s before you take recreational doses unless you wanna rape your liver.

Tylenol 2 by Qwertyuiopqwer July 10, 2016

20 Tylenol 

When you really mean serious business on the internet, and you're gonna end it all for real this time, 20 Tylenol is all you need.

Forumer #1: You're a faggot.

Forumer #2: 20 TYLENOL! I'M SERIOUS THIS TIME AND POSTIN' IT ON MY LIVEJOURNAL!

Forumer #1: Still a faggot.

20 Tylenol by Mr. Wollamhs June 13, 2008

Nature’s Tylenol 

Taking a shit and rubbing one out after. Two natural things a guy does to feel better.

Pat woke up with the worst hangover so AJ and the boys suggested he take some of Nature’s Tylenol to feel better

Nature’s Tylenol by Not Chiefsaholic June 15, 2023

Tylenol 

North American brand of a painkiller whose active ingredient is acetaminophen (AKA paracetamol outside North America).

Don't take more than the recommended dose of this stuff (or of any other paracetamol/acetaminophen based painkillers). Overdose can cause liver failure, a fairly unpleasant way to die.

There are tales of people overdosing on tylenol/paracetamol pills one evening, and waking up the next morning feeling sheepish... they go about their business as normal, then later that afternoon start to feel really ill, get rushed to hospital and die shortly afterwards because their liver is knackered.

You really do *not* want to overdose on Tylenol/paracetamol. Trust me on this one.

Tylenol by Durban Ictionary April 21, 2007

Tylenol With Smack 

A term for the mixture of Tylenol PM and heroin also known as Cheese.

...and keep off the Tylenol With Smack

Tylenol With Smack by Dr Ivo Šandor June 13, 2010

tylenol pm challenge 

Taking a handful of Tylenol PM and then trying to have an orgasm before you fall asleep. Something that has been rumored as impossible by old people everywhere.

Hayden- "I just did 50 pull ups!"

Luke- "Please, I have completed the Tylenol PM challenge the past three nights in a row."

Hayden- "Nigger please, your shitting me"

tylenol pm challenge by Cool_Hand_Luke December 1, 2013