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To drink to the point of extreme intoxication. Synonymous with tie one on.
Eric: I think I'm going to tie one off tonight.
by littlebadger June 19, 2009
to shoot up drugs intravenously
Delina wanted to really "tie one off" so she bought a teener from her dealer.
by steelslinginslut June 04, 2009
The act of having sexual intercourse.
If my date goes well, I plan to tie one off.
by Chumpbuster January 23, 2009