Part of the relationship base system. Means to not even ask someone out, thus making no progress.
Bro, how are thinks with you and Jill?

I decided to not ask her. I got a looking strikeout.
by jrush0815 September 19, 2016
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When you chase a double-shot of tequila with a double-shot of Tapatio. Optionally, the subject may also snort a line of salt as either the first or third step.
Jose drank so many Mexican Strikeouts that he did not even realize that he was the victim of double anal.
by KelleyRoss August 14, 2009
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Similar to a normal "strikeout," but with a Mexican twist! To enjoy a Mexican Strikeout one begins with a hefty bong rip, followed by a shot of tequila, chased with a full Mexican beer, and finishing with the exhalation of the bong rip.

Popular Mexican beers include: Dos Equis (XX), Tecate, Modelo
Met up with some of my friends today; Mary Jane had bud, Pablo had Sauza, and Luis had Tecate. We all knew this could only mean one thing, Mexican Strikeouts!

We were all FUCKED up!
by Lita Chiquita July 24, 2009
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The act of taking a drag from a cigarette, sipping a milkshake, and then exhaling.
Jim: "I was at the casino yesterday and a saw a woman in sweatpants doing a whitetrash strikeout!"
John: "What kind of cigarettes was she smoking?"
Jim: "I don't know, but it was a chocolate shake!"
by VacationDad May 20, 2013
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While a standard strikeout involves weed, beer, and a shot,
the Virgin Strikeout consists of pouring a whole pixie stick into your mouth, and then dropping a 5 hour energy into a glass full of monster and swallowing everything.
Matt didn't want to drink at the party, so he decided to try a virgin strikeout instead.
by DGbruin October 4, 2010
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The process of inhaling marijuana smoke, and then exhaling into a females anal cavity, then proceeding to fuck her in the ass and inhaling the smoke coming from the anus and exhaling.
by Anal Strikeout June 7, 2014
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When somebody strikes out after being pitched two strikes and four balls
The Indians just got robbed cause the up called a cincinnati strikeout
by Jon Reed June 9, 2007
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