Top Definition
It is the venereal disease Chlamydia.
Example 1: Used on the show Rescue Me

Tommy: I think I caught the big c.
Lou: No, no. Cancer is the big c, Chlamydia..little c

Example 2:
The little c makes my piss turn to fire.
by rdff41 June 27, 2006
7 Words related to the little c

Free Daily Email

Type your email address below to get our free Urban Word of the Day every morning!

Emails are sent from We'll never spam you.