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It is the venereal disease Chlamydia.
Example 1: Used on the show Rescue Me

Tommy: I think I caught the big c.
Lou: No, no. Cancer is the big c, Chlamydia..little c

Example 2:
The little c makes my piss turn to fire.
by rdff41 June 27, 2006

Words related to the little c

chlamydia clap dirty sex ghonorrhea std sti vd