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1.
A phrase refering to cancer, a very deadly, cellular disease in which normal cells mutate and spread throughout the body or a localized area in the body...
"It's not fair... I don't even smoke and I got the big C..."
by UsurperOfLife April 12, 2005
 
2.
An ultimate act of relaxation that may or may not include ones family or friends. If you’re just “hangin” with your friends, with no real purpose or direction to the day, you’re probably doing the “Big C.” To be “chillin” alone or in a group constitutes the act of doing the “Big C”.
“What’s up Bro?”

“Nothing really; me and my girl are just doing the Big C”.
by Nevado August 19, 2011