you've been here to long,take a powder
Chill out...relax...calm down. As in "Go powder your nose or something (for a guy, too) and CALM THE FUCK DOWN"
?! Are you on the rag
or something? We were TOTALLY kidding. Go take a powder and your beer'll be here when you get back"
Stop bothering me and/or relax yourself, specifically by taking a break in the powder room. There you can put some talcum on your face to cool off. See go take a swim
and fly a kite
. Old fashioned.
Richie: "I only meant it playfully."
Richie: "Go take a powder!"
Mary: did you hear? johnny decided to take a powder yesterday.
Jake: When's his funeral?
To take a crap.
Uhhh sorry, where is your bathroom? I need to take a powder...