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1.
to urinate(see also piss, whiz)
I was on the bus for so long, I had to take a leak when we got to our destination.
by Light Joker December 25, 2004
 
2.
(Informal) to urinate, to piss, relieve oneself. (Crude. Use caution with the topic. Usually in reference to a male.) I gotta take a leak. Man, it felt so good to finally take a leak.
I gotta take a leak.
by Fearless Freddie July 17, 2014
 
3.
In the author Kurt Vonnegut's novel, this phrase means: "To steal a mirror."
Truck driver- I gotta take a leak

Kilgore- Where I come from that means you are about to steal a mirror!
by punman March 12, 2009