A sexually transmitted infection.
Hey John I spent hours last night googling STI to get some relief, I cant take this itching anymore.

Its it Ironic how the owners of cant get rid of their site.
by eldudebrothers May 31, 2011
An abbreviation for "successful troll is successful."
Jim: Yo, Korea! Starcraft sucks!
Jim: STIS!
by Ban-Ki Moon November 05, 2010
Stevenage Transmitted Infection - like a sexually transmitted infection but the origination of the infection is from Stevenage, most likely the leisure park.
My mate from work caught an STI after chomping into a girl on the leisure park
by Bestos001 September 29, 2011
Sexually Transmitted Infection/Illness

Another way to say STD (Sexually Transmitted Disease)

Is usually tranmitted through vaginal sex, oral sex, and anal sex, but can be transmitted through breast milk, blood transfuisions, and shared drug needles, among other things.
STIs are so much fun! ...Not! Chlamydia, an clap silteach(Gonorrhea), Syphillis, breac bhoiceannach (Herpes), lionnachadh-grùthain (Hepatitis), an galar seirge (HIV), is that really worth sex without a condom? Throw you life away with one little fling?
by Lorelili March 19, 2005
Sexually Transmitted Infection
I got an sti after gangbanging all those dirty ass ho's.
by veeco January 01, 2004
Pronunciation: "stee" not "ess-tee-aii".
Swear word in Québec.
Abbreviation of wordESTIword or wordOSTIword or wordASTIword
"Le film à voir avec ta tête sti".
"Sti d'imbécile".
by StéphaNapkiN July 24, 2003
Scandalous Type Individual/s

1) She hella mean and if your bootsy she'll tell you , she a STI
2)They stay geesin , no wonder they some STIs'
by Bossy-1 July 27, 2006

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