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screw you billy 

What Jacksepticeye says during happy wheel gameplays, usually while playing the character known as "jb"
Jack: I died again!?! SCREW YOU BILLY!!

the screw you effect 

A psychological term. When a participant is in an experiment you may not get accurate results because they are aware of the experiment and in turn go out of their way to do everything wrong or go against everything u ask them to.
scientist 1 "this guy is doing everything wrong"
scientist 2 "ah a classic case of the screw you effect"

screw you 

a nicer way of saying fuck you. usually used when annoyed.
Retard: Pudding sucks!
Pudding lover: well screw you.
screw you by Sarah Ca December 25, 2007

screw you guys im king lesbian 

when your local kwel jewish friend is in love with his lesbian teacher but yet doesnt know what lesbain means so---
Kyle "screw you guys im KING lesbian"

SCREW YOU 

Said either jokingly or when someone's honestly annoyed with you. Means GO THE HELL AWAY because I HATE YOU. Or, simply, eff you. Similar to WHATEVER or EFF OFF
Karm: Dude your boyfriend's effing hot.
Sue: Screw you.
SCREW YOU by Miss AnGie January 19, 2003

Screw you and your box

Meaning screw you and your household but you are implying thaat they are poor and they live in a cardboard box thus making it more insulting.
Screw you and your box then!