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1.
A LEGAL subsitute for weed. It gets you high and will not show up on drug test. Must be 18 or older to buy it.
Sammie: lets go and blow down
ME: yeahh i got this fiya shit spice so i wont fail my drug test!
by probationsuckkks June 20, 2008
 
2.
Contrary to what the other definition for this term may say, "spice" generally does not refer to 2C-I or any other 2C-x compound for that matter. Usually when one refers to "spice" they are talking about N,N-Dimethyltryptamine (DMT), the powerful and short acting psychedelic often smoked in base form or taken orally with an MAOI.
"I loaded some spice into my pipe and took a dive into hyperspace"

by (Omni) April 03, 2008
 
3.
Spice, also known as "synthetic marijuana", "legal/fake weed", "K2" etc., is a drug created by spraying herbs with synthetic chemicals that, when consumed, allegedly mimic the effects of cannabis. It's effects are much stronger than those of natural marijuana, and although not thoroughly researched, are known to be dangerous.

Seriously, there is NO reason for this stuff to be legal. Along with bath salts, this is probably the second most dangerous shit you can put into your body without getting into law trouble. It feels like you have been poisoned by someone, extreme shivering and paranoia, vomiting, increased heart rate... You could say it has weed's effects, minus the fun.

This stuff is a RESEARCH CHEMICAL. While you're buying it, you should probably ask yourself why are you buying fake weed in the first place, because if you're gonna go this far just to get "high", you shouldn't even be getting high, you're addicted.

You do not know with what this stuff is sprayed with, and it can have REALLY traumatic effects on a first-timer or even an experienced marijuana user. I've had people tell me that spice totally ruined weed for them later on.

Spice is poison. DO NOT smoke this stuff. Seriously, awareness campaigns should be started just so people know what this shit is. Yes, some states in the US have criminalized it, but it is still 100% legal in most of Europe. You've been warned.

source: Personal experience + frient of mine collapsed after one hit.
Ents around the world, don't do spice. You're better of smoking the real herb, trust me on this one.
by electrojesus November 25, 2013
 
4.
Slang for girl or female.. often used only to describe a female considered beautiful or equivalent.
I saw one hot 'spice' today bro..

Fam I was With this girl and she was looking 'spicey'

Im going to link one 'spice' at her house still
by Razor Ramizzle September 11, 2012
 
5.
Some sh*t for food which makes it taste better
You like my chili? I added some spice to detract the taste of the dog food I used. XD
by dumbwiz June 14, 2011
 
6.
The reason why Europeans went looking for the West Indies ... according to their letters sent home to their wives and children.

Not to be taken literally - the explorers actually meant spices as in sexy tan Indian women.
Columbus: Yo Dona, I found so many spices. I'm going to be so f'ing rich when I sell them!

Dona: (to self) I love it when my man isn't home

Columbus: (to self) Sexy hot women! Woo-hoo!
by Mr. 29 September 26, 2010
 
7.
Plural of Spouse
Useful in non-monogamous relationships where several spouses exist.
Everyone wanted to go to the zoo, but on the morning before, one of your spice gets a call to go into work that day.
by Dny March 05, 2014