a) To make a sudden and unplanned movement, a twitch, usually caused by being so stoned u just flinch for no reason and the person sat next to u thinks ur weird.
b) When you have consumed too many drugs/too much alcohol and u blackout on the floor and twitch when you are unconcious. (an epileptic fit is also known as a spazz out)

A slang term from the Great State of Texas meaning a physical or verbal burst of energy with negative or positive intentions.

Most Pimps and Players understand the need to spazz out on these hoes.

Its when you go completely bonkers, if you're mental, or when you have a mental disease. Other times you could be complete retarded