The act of smoking pot with your friend and then ditching them just to get high. Which is usually done when you have ran out of your own pot to smoke.
Joe: Dang I just realized how late it was, I'd better go, I have to be at my girls place at 9 tonight.
Matt: Bullshit! I got you high, you can't Smoke & Run that shit is old school!
Matt: Bullshit! I got you high, you can't Smoke & Run that shit is old school!
by Stoney Rock February 27, 2011
The art of smoking and stunning an entire room in rainbow six siege in which you do not kill anyone and escort the hostage without anyone knowing.
by Mr. Siege Pro Meister March 26, 2018
It's when get in a fight with one of your opps and you shoot them and that's where the smoke part comes in. The gun is smoking and they just got smoked.
Guy 1: Did you hear those gunshots last night?
Guy 2: Yeah, he tried running smoke with some gang members.
Guy 2: Yeah, he tried running smoke with some gang members.
by IllRunSmokeWithYou July 11, 2021
I loved the scene in Dazed and Confused when those kids were fucking up mailboxes during their smoke run.
You want to go for a motherfuckin smoke run after this beer?
You want to go for a motherfuckin smoke run after this beer?
by PulpFictionFan94 September 10, 2017