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1.
Mid 90's slang used to express question along with surprise. Commonly substituted for the phrase "for real?!"
" I parked my car downtown and some asshole smashed out the windows and shit in my seats," Jamal exclaimed.

"Skow!" Chameel replied.
by Old man withers August 03, 2005
 
2.
skank and cow put together.
bec is a very big horny skow.
by Aj, Am, Ej June 18, 2005
 
3.
A quiker way to say lets go for lazy people like me.
I had too much Taco Bell today. Skow home so I can drop bombs.
by Ricky Possum (aka Gumdrop) September 02, 2004