The quickest way to respond to someone who is trying to make fun of you or being annoying in general. This will cause the person to have a confused look upon reply.

Similar to sure.
Brian: "Yo stop staring at that guy's ass."
Tom: "Siure"

(2) Brian: "I don't know why you never clean up your own dishes. It's getting ridiculous."

Tom "Siure"
by LordKoonhammer April 13, 2011

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