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The dominant partner in a gay male on male romantic relationship in Japanese yaoi anime and manga, doujinshi and fanfiction. The seme is said to 'top' his uke. The seme is often (but not always) the older of the two/ more serious/ dark/ mysterious and more 'handsome' than 'cute'.
In the shonen-ai anime Gravitation, the mysterious Eiri Yuki is the seme over the pink-haired Shuichi Shindo.

In Sensitive Pornograph Sono Hanasaki has a seme (Seiji Yamada) a whole ten years younger than himself.
Seme by Su-chan January 11, 2009
Related Words
Japanese for the partner on top. Used in conjunction with uke and yaoi.
Seme by Alyson March 31, 2003
Often referring to yaoi manga, the seme is often in the 'top' when having sex. The seme is usually the opposite of the uke, more experience with sex, mysterious, handsome, etc.
Semes are usually hot.
Seme by MisaTange August 17, 2009
The one who puts it in hole. And is usually taller.
{name} pushes {name} on to the bed, saying that he’ll be the seme. The one who shoves it in.
Seme by Osif June 13, 2019
The person on "top" during sex. Contrary to popular belief, this is not always associated with shonen-ai or likewise
"During sex with my girlfriends, I usually am uke"
seme by AJ and Jimmy November 14, 2003
macedonian word for seed, also used as a greeting
Seme da te ebam
seme by Skankaholic August 6, 2003