The name given to a zit on your back that you can't reach to pop, so it irritates the hell out of you.
Can you pop this self destruct button?
by O.D. Batt August 20, 2010
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The evil version of taking a self-care day.

A chance for a depressed person to abandon all commitments and responsibilities to do things that make them feel terrible.

Extra points if you take time off work or miss an inportant deadline.
Person 1: "I haven't seen you since last week, are you okay?"

Person 2: "I just took a self-destruct day. I slept for 14+ hours, then stayed in bed and rewatched episodes of the US office and ate so much food I couldn't move."

Person 1: "Bro, you need to go back to therapy."
by psykotisk December 4, 2021
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5th studio album by 50 Cent set to be released 9th February 2009. Features the single "Get Up".
"Before I Self Destruct, Motherfucka," - 50 Cent on exclusive "50 For President" track.
by iconmike2008 December 12, 2008
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see Bitch; an unpleasant woman; the female of the dog or some other carnivore.
"Man I hope my boyfriend doesn't turn out to be like Noah; Mr. Self Destruct!"
by Daniel beefpiles December 15, 2006
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The "Self destruction phase" is a phase in which people suddenly become distant or plain assholes with multiple of their so-called friends. This typically happens in High School.
Girl 1: Why has Abby been saying weird things to me and leaving me on read?
Girl 2: I heard she was in the Self destruction phase.
by LinkCanBackflip November 6, 2019
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This is when a person is so bad and evil you don’t even need to do anything to attack back or defend your self. Because what they doing defeats their self and destroys their own life in ruins or even gets them killed.
Whoa he’s so self-destructive, he made the house cave in on his self and killed his self destroying everything inside causes this and all the beams. And also started a fire with no way to escape out.
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When a female (more commonly young less experienced stupid chick) does or knowingly lets others do freaky

stuff with her vaginal regions that could potentially cause harm. Generally sexual in nature. In most cases alcohol or other recreational drugs could be involved.
“Becky needs to chill out! There’s a difference between A one night stand and sleeping with the whole bar plus there mom too! It’s like she’s stuck in Self Uteral Destruction mode....”
by RhianneSaurusRex May 17, 2018
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