1.Calling someone out for a fight..
2.Running the fair one
ANGEL: U AINT GONNA DO SHIT
SALLY:"Wuss good then, run me the ones right now"
ANGEL: Aight bitch wuddup?!
Joe: yo! they bout to run the ones!
by NYDREE October 5, 2006
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It means the same thing as when you tell someone to fight you, mix you, throw hands, or any other term
by Bigblackducl August 3, 2017
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To play a single game of something, usually a pick-up sport.
*Sees three people sitting next to a basketball court*

"Aye, y'all tryna run one?"

ALTERNATIVELY

Friend: *Stares at your copy of Super Smash Bros sitting on the table*
You: "You tryna run one?"
Friend: "Run them hoes then!"
by Yodaddybitch August 11, 2017
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To masturbate, usually referring to guys only. The term is used when a guy has the urge to whack it after seeing a hot girl.
I was dancing with this hot chick at the club, but I didn't go home with her. When I got home, I was so horny that I had to run one off.
by RexGibson March 6, 2004
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