Slang for a one on one fight; alternate spelling of "Run the ones." Denver youth often run the ones with "Dirtz" or "Do-Dirts" which are boxing gloves they carry with them, often at their jeans back pockets.

After running the 1s you might have to "run the twos" (run it back)."
That boy was trippin so I told him run the 1s cause today I got time cuz!
by MississippiIncenseMan February 14, 2023
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Basically telling someone to fight you.
Person 1: Yo, I heard you was talking all that shi, run my 1s tomorrow.

Person 2: Igh bet, you and ****** run my 1s tomorrow at 10:30.
Person: Igh.
by sisbedefiningshi February 9, 2022
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Asking for a 1v1 but with confidence and a healthy amount of toxicity.
Player 1: "run 1s kid"

Player 2: "ok fodder"
by ilahiboykot August 20, 2023
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