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1.
Because Cain was the first murderer in the Bible, having killed his brother Abel, people use the expression "raising Cain" to describe acts of violence, criminal activity, or any other mischievous acts.
Robert: Whatcha gonna do tonight?
Michael: Nothin' much. Guess I'll just be out raising Cain.
by Tina R. Collins November 10, 2005
 
2.
raising Cain:

1. The act of raising or striking with a cane in anger.

2. Raising Cain from the grave, as in biblical times. (Cain and Abel brothers.)
1. Johnny was raising Cain.

Johnny was so hurt he began raising Cain. (Woke the dead.)
by Carolyn N. Holtzman July 09, 2006