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An annual spring event at Radford University involving free live bands and food where students (and some faculty) begin drinking at 12pm on thursday, drink straight through the weekend, and stop drinking at 8am monday. Some years they even have to bring in the National Guard to control the drunken insanity.
"it's 10am on a friday and you're drunk already?!?"
"IT'S QUADFEST!"
quadfest by unknown April 16, 2005

myspace quadfecta

When you get comments, messages, pic comments, and friend request when you sign in
damn yo i just got a myspace quadfecta

quagfest 

Quagfest is a celebration hosted by Glenn Quagmire in honor of his 1000th sex partner.
Appeared in the episode "Fighting Irish"
I was invited into the quagfest and the event is prefaced by a parade featuring Quagmire's sex partners from around the world.
quagfest by ProfessionalCanadian! November 11, 2015

Queefestra

A musical ensemble, most noted for their woodwind section, who preform classical concerts with the wind of their vaginas. They can often be recognized by their costume which consists of crotchless unitards and white rhinestone bowties. They are backed up by their road crew who follows the the motto "You Blow'em we Stow'em".. Coming to city near you...
The Queefestra's performance of the Ovature of 1812 really blew my hair back last night.

Have you ever heard of the Queefestra? NOW THATS TALENT!!!
Queefestra by tmm05 February 11, 2006

Quadfecta 

When Mario Kart is being played, and a player gets last place all four races.
Player 1: Jim got the quadfecta!
Quadfecta by Iced_ September 1, 2017

quadfecta 

A legendary beirut/beer pong shot that lands on the tops of four cups simultaneously. Considered the rarest shot in the game, topping even the trifecta, 2-cup knockover-and-sink, and simultaneous 6-cup game-ending double bounce-in. Counts as 4 cups and has never happened in recorded history of the game, despite being theoretically possible.

So rare for the following reasons:
1) Only possible with smaller-than-average cups.
2) Only possible when cups are arranged in a perfect square formation (not possible in a standard game).
3) The physics of it happening are similar to those of the trifecta, which almost never happens in itself.
Witnessing Dan's game-ending quadfecta in the semifinals of the Theta Delt beirut tournament was a thing of beauty comparable to seeing the face of God Himself smiling down on you from the heavens.
quadfecta by Nicholas D December 24, 2007