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1.
noun: used to describe someone who is a retard, dumbass, fuckface or a any thing related to that

"That fuckin' pusshole took my money"

"Yo pusshole what's up?"
by DrMrPac November 02, 2008
 
2.
Referring to one who is the worst form of a pussy.
"Jared is such a puss hole. I've met a lot of pussies in my life, but he's the worst!"
by C-dizzle23 December 17, 2009
 
3.
When a chick gets fucked by a huge dick and her pussy and asshole become one big hole.
Holy shit Denise, that guy I went home with had such a thick dick, I now have a pusshole!
by Guessume May 02, 2012