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1.
To optimize in the extreme, particularly as in computer programming.

The transposition of characters refers to the common experience of dramatic optimization breaking functionality or correctness.
I totally potimized the hell out of that function. Sure, the results were different, but it was 57x faster!!1!one
by _jrk_ March 18, 2009
 
2.
the act of showing someone how to smoke weed for the first time, and turning them into a marijuana smoker.
I potimized like 5 of my friends this week
by mrhood58 August 22, 2013