Yiddish slang for bowel movement.
I was so scared I almost plotzed in my pants! I laughed so hard I almost plotzed in my pants!
1) so garbled, confused, distorted, or otherwise messed up as to be utterly unsalvagable.
2) so intoxicated as to be unintelligible or incoherent.
1) Your computer is plotzed.
2) Ralph got so plotzed last night that he couldn't even give the cab driver directions to his house.