1. moving from place to place

2. running from the police
I almost never eat breakfast while on the run.
by Light Joker January 20, 2007
Commonly used to say someone is moving, but not in this case. In this case, it can mean, crazy, weird, or annoying.
Madison and Neal are on the run.
by katy. taylor. britney. <3 April 07, 2010

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