Sort of like "you do you," but with a strong implication that you're talking out of your ass. Basically "you're an idiot and what you're saying is stupid, if you want to keep going I guess I won't stop you."
Bob: "The world is run by lizard people."
Sue: "There's no such thing as lizard people, but go off, I guess."
Sue: "There's no such thing as lizard people, but go off, I guess."
by Mai Ainsel July 1, 2020

by Scratch 'N Sniff Asshole March 4, 2021

you say this when your friend says something that proves you were wrong, but you don't want to admit it.
Gasinah: The answer to the math problem is 26, your paper says the answer is 76. you are stupid.
Jaakawbie: go off i guess
Jaakawbie: go off i guess
by mckenzielovesgrapes March 15, 2019

Similar to a book off, where someone would ignore the person sittting next to them by reading a book, but in this case the person would put their headphones in and listen to their i-Pod instead. This is usually done when the person sitting next to them is annoying them, etc.
by hozz12 April 23, 2009

guy 1: Look, just cuz the hottest girl in school dumped you doesn't mean anything. *puts arm around guy 2*
pissed off guy 2: Take it off before I break it off.
pissed off guy 2: Take it off before I break it off.
by Keith Hutch. October 9, 2007

It is said when one has taken a large burden off their shoulders, such as completing coursework, having sex, or having their braces taken off.
by Partisan Passers-By Proxy July 25, 2016

by xulapa October 1, 2014
