Top Definition
Crazy, as used in "Wedding Crashers".
I'm terrified of this girl. She's completely off the reservation.
#crazy #bat-shit #looney tune #level five #nutjob
by JtotheL March 01, 2006
Highly offensive saying referring to American Indians that have left the reservation.
That crazy drunk, he's gone off the reservation.
#american indian #reservation #drunk #crazy #republican
by ClancyMan September 04, 2015
Going of the reservation is when certain elements such as spies or assassins either fail to complete an assignment/mission, go on an unauthorized mission, get caught and spill their guts, or go rogue. Usually resutlting in the need to neutralize(kill their ass) the said element.
lopez: hey man did you hear about that guy joe who worked with me at the CIA?
jimmy: no man what?
lopez: he went off the reservation and so I had to kill his stupid ass for going rogue.
jimmy: well thats what you get for trying to fucking double cross the CIA.
by mr. shakedown September 04, 2005
A term sometimes used when a made man in the mafia kills another made man without the permission of his superiors.

A term sometimes used when agents in a spy agency, such as the CIA, go on unathorised assignments.
The Sopranos: "Tony B went off the reservation and wacked Billy Leotardo."

Spy Game: "If you go off the reservation, I will not come after you..."
#off #the #reservation #reservations #definition
by Fablo April 27, 2007
a point in time when highly intoxicated or in another state of mind, may result in streaking and/or skinny dipping and blurred memories of the night before.
tonight im going off the reservation, please pick me up in the morning
#drunk #wasted #beer #college #naked
by YouLikeThis-JMART April 29, 2011
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