1) Girls who are bullies and use "girl agression" (nasty comments, trickery, deceit, excluding people from events, spreading rumors, stealing boyfriends,etc.) to manipulate other girls. They will use text messaging, AIM, email, three-way-calling, and any other weapon at their disposal to acheieve these goals.
(coined by Rosalind Wiseman in her book "Queen Bees and Wannabees")
These girls are often popular because everyone is either afraid of them or wants to be like them. They tend to have armies of followers ("friends"/wannabees) comprising their clique. However, few people actually like them for who they are.
2) A movie based on Rosalind Wiseman's book "Queen Bees and Wannabees" which takes an intimate look at the inner workings of a high school and the all-powerful girl clique who seem to run it. Starred Lindsey Lohan before she went blonde and possibly anorexic, and therefore was still "hot" (see some other definitions). Very highly watched among the high school population as many girls could actually relate to the story.
1) "Those popular girls are always fighting with each other and manipulating everyone else. They're real Mean Girls."
2) "Yeah, I've seen the movie Mean Girls too. Wasn't it great?"
by andriod5 August 29, 2005
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Mean Girls rules beeotches!
Mean Girls is so fetch!
by beeoyth January 19, 2007
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Girls that range from ages 8-22 (average) that believe the world belongs to them and them only. They gossip about anyone that stands up to them and ruin their life.
Popular girl 1: OMG, like, Brittany totes has the ugliest shoes!!
Popular girl 2: and did you see her makeup? UGH
They such mean girls
by bone-app-the-teeth June 11, 2014
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Girls that are preppy and snobby, usually the person describing them as mean isn't much better.
It can also be a phrase meaning that you wanna have sex with lesbians.
Person 1: Mean girls!!!
Person 2: ...Did you mean what I think you meant?
Person 1: :)
by sorrysauce July 20, 2006
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a movie you masturbate too
I just got my welfare check in today so I decided to go see Mean Girls.
by kRaZyToM April 30, 2004
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Mean Girl - is code for dominatrix. product of the millennials generation safe-code texting.
Can you hook me up with good mean girl this weekend? Slaves must ask mean girls for permission to release themselves.
by Crimson Habit April 5, 2016
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Possibly the best movie ever. It was written by Tina Fey. It's about a girl named Cady (played by Lindsay Lohan) who moves to a new school and becomes friends with a clique of bitchy girls, who are nicknamed the Plastics. Cady turns into a mean girl from hanging out with the Plastics, but in the end she realizes her mistake. It's just about the most quote-able movie ever.
Quotes from Mean Girls:

Damian: "Ohmigod Danny Devito I love your work!"

Gretchen: "I don't think my father, the inventor of toaster strudel, would be too pleased with this."

Regina: "Boo you whore!"

Karen: "It's like I have ESPN or something! My breasts can always tell when it's going to rain. OK...they can tell when it's raining."

Janice: "Regina George is not sweet! She's a scum-sucking road whore. She ruined my life!"

Some weird chick: "One time, she Regina punched me in the face. It was AWESOME."

Cady: "Grool"

etc.
by Sohcahtoa January 2, 2009
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