Being extremely strapped for mana, that is, not drawing enough lands/other mana sources to cast the majority or entirety of the spells in your hand.
Normally, if you are manascrewed, you will be trashed.
Opposite - manaflood
"ARGH! That's the 14th draw in a row I've not scored land! Manascrew!"
Term used by agitated players of the collectible card game Magic to describe a state of unequal distribution of land cards.
"Awww fuck fuck fuck, goddamnit all! This is NOT need right now- damnit I'm so being manafucked up the ass here!!!"