Top Definition
the intravenous injection of a drug. which means using a needle to get a drug into your vein, to absorb it through your bloodstream. a lot of drugs can be taken this way, the most commonly associated drug being heroin.
Layne accidentally overdosed by mainlining heroin.
by two blue lights November 10, 2008
The act of binge-watching or binge-listening all episodes of a podcast or all episodes in a season of a TV show without breaking for sleep.
Mackey: Where were you last night?
Buddy: Aw, man, I was mainlining "Sense8." After the second episode, I was addicted!
by GypsyBowl July 20, 2015
the act of taking internet lingo and applying it to real life conversation

matt: I walked by a group of kids taking a test and said, "fucking scrubs."
joel: dude, you were totally mainlining.
by Taxt April 16, 2009

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