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1.
One who does drugs such as heroin by means of shooting up in a vein. Intraveinously
Hes a mainliner druggie
by Kyleigh January 26, 2006
39 8
 
2.
One who injects drugs into their bloodstream with a needle.
Ohmygod, he's not only a mainliner, he reuses his works! Do not exchange any bodily fluids with him no matter what.
by mjrn February 25, 2006
25 4