To get "high" on heroine through the means of an introvenus-needle. I.e. - Shooting up.
Addict: Yo, dog... Yo got the shit to lemme rock tha mainline?
Dealer: Fo' sizzle ma nizzle, that'll be fiddy.
by God May 20, 2003
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A killing in which drugs are shot into the veins. Used in the song by Lars Frederiksen and the Bastards
I said a mainlining murder baby (part of the lyrics)
by Mardy blackardy October 18, 2010
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pursuing (somone, something) with an intensity that keeps you up from Page Zero to Page Zero
Jasper and Kelsey stayed up all night mainlining after a good acronym for the pres search
by thresky October 21, 2022
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