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1.
Mahoo is Hawaiian slang for a homosexual.
"I couldn't believe it when I found out my cousin was mahoo."
by hitokage May 09, 2005
 
2.
A word created in Massachusetts in the early 1980s to denote a mentally retarded individual, or a "Special Education" student.

Pronunciation is heavily stressed on the second syllable: "Ma-HOO!".
Hey MaHOO!
by Insomniac Girl November 28, 2010
 
3.
1. A word to express any emotion ranging from agreement to defeat depending on the rise and lowering of its pronounciation. Also used as "mahoo'en" or "mahoo'ed"
Janice was all mahoo'ed out.

"Should we stop?" "Mahoo."
by kelly August 08, 2004