Someone being of or like a really mean person, specifically and cranky music teacher. They tend to say maaaahhhhh when they are angry. You can use it as any part of speech.
The teacher was totally being all mad cow disease last night. She was all " maaahhhhh"
by bindy havanah December 23, 2008
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(n.) A condition in which an individual is nagged and/or afflicted by a raving cow. Also known as marriage.
Poor Jim has a bad case of Mad Cow Disease.
by ChriSe7en July 13, 2009
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A legitimate medical term for the symptoms of P.M.S.

A woman with Mad Cow Disease is referred to as a mad cow.
Matt, "Thanks for taking me to the indian casino to play poker tonight. I had to get the fuck away from my wife before she drove me nuts."

Jeff, "You're welcome. I knew you needed it. According to my calender she's got mad cow disease this week."
by dooshkanew August 23, 2009
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Ketamine Hydrochloride. So called because it induces a stupour in users not dissimilar to mad cow disease.
by Anonymous May 27, 2003
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Feeding a cow animal by-product resulting in giving the cow serious constipation therefore having an angry cow.:{
The cow looks mad he must have that mad cow disease he has'nt shat for a Week
by Triple D May 6, 2005
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