Top Definition
L.S.D.H.I.S.O.S = Laughing So Damn Hard I Shit On Self.

Uncontrolable laughing that is so hard you shit all over yourself and it is awesome.

PS: its mexican yeeeee >:0

Man i am LSDHISOS over that funny ass joke you just told me a second ago because it was hilarious and i heard it and it was cool.
by Tommy Joe Robertson Jr. April 07, 2010

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