A fictional setting in the Grand Theft Auto titles San Andreas and GTA V, based on real world Los Angeles.
hey dude, Los santos looks like L.A
that's because it is L.A you twonk
by bakuboy October 4, 2013
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Los Santos is the city with the highest crime rate in the U.S . The city of Los Santos was founded in 1781. Los Santos is the largest city in the U.S state of San Andreas.
Los Santos is a dangerous city.
by Würstelchen May 3, 2020
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A chain of vehicle customization shops in Grand Theft Auto V. Has a spray can icon on the minimap.
I just customized this Warrener in Los Santos Customs.
by TidePodIngebrigtsen69 May 25, 2016
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A method of execution in GTA V Online whereby one disables a Deluxo’s hover mode in midair, causing it to fall on an unsuspecting victim and crushing them like a bug beneath a boot.
"See that griefer down there? How about we fly over there and give him the ol' Los Santos Stomp."
by CapedCamish September 24, 2020
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A very shitty roleplaying game on the San Andreas Multiplayer mod for GTA San Andreas. Consists of mostly scammers, robbers, gang members, and policemen so there's not much of a variety. You work hard for your money and to end up getting it all robbed at the end. Yup, even the policemen jail you and ticket you for no reason just to earn money. The game also consists of 9 year old admins and players, so if they don't get what they want they be a bitch about it. The economy really sucks ass too because there are billionaire gang members and millionaire policemen. They're all e-money hungry. Most of the houses are taken by players who quit or never log on anymore.
After fishing and working hard for money for a long time:

Robber:(holding gun up to you) GIMME UR MONEY OR I KILL YOU- AND DON'T LOG OFF OR I REPORT YOU

Hard Worker gives Robber his money.

Robber: HAHAHAHA THANKS NOOB ALL YOUR HARD EARNED MONEY IS MINE NOW!!!!111

Typical day in Los Santos Roleplay
by LSRP Sucks January 11, 2011
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Used in Mexico, when a woman sticks a finger in a man's anus during coitous to maximize sexual ecstasy.
Guy1: You look so relaxed dude, did you get laid last night?
Guy 2: Yeah! this girl was so into it she gave me a "De los Santos" and I finished so hard I was left with no energy.
by androst July 28, 2011
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A high-end university run by Lamar Davis which teaches its students the science of roasting, especially yee-yee ass haircuts. It is located in Los Santos, San Andreas, USA.
Person 1 : Can i come to your house?
Person 2 : No, we will meet tomorrow at work
Person 1 : Ah man, don't hate me because I'm beautiful man, maybe if you got rid of that old yee-yee ass haircut you got

you would get some women craving for your penis. Or better yet, maybe Tanisha will call your desperate arse if

she stops enjoying coitus with that brain surgeon or lawyer she is making love with. NIGGAAAAA
Person 1 : what?

Person 1 : Do you go an university or do you work?
Person 2 : I go to the Los Santos Institute of Roastology
by weenerwilly January 18, 2021
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