Means when you are ready to lose your temper
You are about to get on my last nerve if you keep asking stupid questions.
by JudiiIvashkov-Black February 23, 2014
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The final point of remaining calm.
That bitch is on my last good nerve
by Mighty B July 23, 2003
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The final point of irritation before drastic action is taken.
I'm on my last gay nerve here, one more crack like that and I'm setting fire to your hair!
by Scott Mansfield October 24, 2007
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